Profhilo is one of the most significant innovations in aesthetic medicine of the past decade. Launched in 2015 by IBSA Derma — the dermoaesthetic division of Swiss pharmaceutical company IBSA, with over 70 years of hyaluronic acid expertise — Profhilo introduced an entirely new category: bio-remodelling. Not a filler, not a traditional skin booster, but a patented stabilised hyaluronic acid treatment that works with the skin's own biology to restore firmness, hydration, and radiance from within. With over 10 million treatments performed worldwide, Profhilo has become one of the most trusted names in professional aesthetic skincare. Enjoy free UK delivery over £50 and explore our Profhilo collection today.
About Profhilo — The Science of Bio-Remodelling
Profhilo is manufactured in Italy at a U.S. FDA-approved facility using ultrapure hyaluronic acid produced via bio-fermentation. Its defining innovation is the patented NAHYCO® Hybrid Technology — a thermal stabilisation process that combines high-molecular-weight and low-molecular-weight hyaluronic acid (64mg in 2ml) without chemical cross-linkers, creating a stable Hybrid Cooperative Complex (HCC).
Unlike conventional dermal fillers, Profhilo does not add volume or contour. Instead, it spreads evenly through the tissue, stimulating the skin's own production of collagen, elastin, and other extracellular matrix components — delivering deep hydration, improved skin laxity, firmness, tone, texture, and radiance with entirely natural-looking results. Browse our full skincare collection and face skincare edit for more professional-grade skincare.
- NAHYCO® Hybrid Technology — patented thermal stabilisation combining H-HA and L-HA without BDDE cross-linkers
- Bio-remodelling, not filling — stimulates collagen, elastin, and extracellular matrix production for natural results
- BDDE-free — no chemical cross-linkers; a cleaner, more biocompatible formulation
- Over 10 million treatments worldwide — one of the most clinically validated aesthetic treatments available
- Swiss pharmaceutical heritage — manufactured by IBSA, with 70+ years of hyaluronic acid expertise
Our Profhilo Products
Profhilo® H+L (1 x 2ml) — Injectable Bio-Remodeller
Profhilo® H+L is the original injectable bio-remodelling treatment — a stabilised hyaluronic acid product intended for professional use in the treatment of skin laxity and tissue quality. Administered via the BAP (Bio Aesthetic Points) technique using just 5 injection points per side of the face, it delivers deep hydration and stimulates the skin's own regenerative processes. Results are typically visible from the first treatment and last 6–9 months, with some patients experiencing results of up to one year.
Please note: Profhilo® H+L is a professional aesthetic treatment product intended for use by qualified medical and aesthetic practitioners only. It is not a consumer skincare product and should only be administered by a trained professional.
- Active ingredient: Stabilised hyaluronic acid 64mg/2ml (NAHYCO® Hybrid Technology)
- Indication: Skin laxity, loss of firmness, and tissue quality in the face and neck
- Administration: Injectable, via BAP technique — 5 points per side of the face
- Results: Visible from first treatment; typically lasting 6–9 months
- Origin: European Community (EC); manufactured at U.S. FDA-approved facility
Profhilo® Haenkenium Antioxidant Cream 50ml
The Profhilo® Haenkenium Antioxidant Cream is a topical rejuvenating antioxidant cream formulated for all skin types, designed to complement and support the results of professional Profhilo treatments. Its highly effective formula nourishes the skin and acts as a protective screen against free radicals, shielding against oxidative stress factors including pollution, UV exposure, and environmental aggressors.
Particularly recommended for use after medical aesthetic treatments such as Profhilo® H+L, the Haenkenium Cream supports the skin's recovery and amplifies the hydrating and stimulating effects of the injectable treatment — making it an essential part of a complete Profhilo skincare protocol. It can also be used as a standalone premium antioxidant face cream for those seeking professional-grade protection and nourishment.
- Key benefit: Antioxidant protection against free radicals and oxidative stress
- Ideal for: Post-aesthetic treatment care, daily antioxidant protection, all skin types
- Size: 50ml
- Origin: European Community (EC)
Frequently Asked Questions
What is Profhilo?
Profhilo is a patented injectable bio-remodelling treatment developed by IBSA Derma, launched in 2015. It uses NAHYCO® Hybrid Technology to combine high and low molecular weight hyaluronic acid without chemical cross-linkers, creating a treatment that stimulates the skin's own production of collagen and elastin. Unlike dermal fillers, Profhilo does not add volume — it improves skin quality, firmness, hydration, and radiance from within. It is one of the most clinically validated aesthetic treatments in the world, with over 10 million treatments performed globally.
What is the Profhilo Haenkenium Cream for?
The Profhilo® Haenkenium Antioxidant Cream is a professional-grade topical antioxidant cream designed to protect the skin from oxidative stress and free radical damage. It is particularly recommended as a post-treatment skincare product following Profhilo® H+L injectable treatments, supporting recovery and enhancing results. It can also be used as a standalone premium antioxidant face cream for daily protection and nourishment.
How long do Profhilo results last?
Profhilo® H+L results are typically visible from the first treatment session and generally last 6–9 months, with some patients experiencing results of up to one year depending on individual factors including age, skin condition, and lifestyle. A standard treatment protocol consists of two sessions spaced four weeks apart, followed by maintenance treatments as recommended by your practitioner.
Is Profhilo H+L suitable for home use?
Profhilo® H+L is a professional injectable treatment intended exclusively for use by qualified medical and aesthetic practitioners. It is not suitable for home use and should only be administered by a trained professional in a clinical setting. The Profhilo® Haenkenium Antioxidant Cream is a topical product suitable for home use as part of a daily skincare routine.
What makes Profhilo different from dermal fillers?
Unlike conventional dermal fillers, Profhilo does not add volume, contour, or reshape facial features. Instead, it bio-remodels — spreading evenly through the tissue to stimulate the skin's own production of collagen, elastin, and extracellular matrix components. The result is improved skin quality, firmness, hydration, and radiance, with entirely natural-looking outcomes and no added volume. It is also BDDE-free, meaning it contains no chemical cross-linkers — a significant advantage in terms of biocompatibility.
Professional Skincare, Backed by Science
Profhilo represents the cutting edge of evidence-based aesthetic skincare — a decade of clinical validation, Swiss pharmaceutical expertise, and patented technology that delivers results no topical product alone can match. Explore our Profhilo skincare collection at Oh So Luxe, discover our full skincare collection, face skincare, and beauty brands A–Z — and enjoy free UK delivery over £50 on qualifying orders.